The Puna region is most commonly reached by road from Salta or San Salvador de Jujuy, both of which provide convenient starting points for exploring Argentina’s high desert. From these cities, routes climb gradually through dramatic mountain landscapes, with winding roads and significant changes in elevation along the way. Journeys can take longer than expected because of the terrain, road conditions, and frequent stops for scenic viewpoints. Starting early gives travelers more daylight for the drive and allows extra time to reach remote destinations comfortably.